101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Statements of Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 107 - Disclosure - Organization and Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Investments and Fair Value Measurement link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Research Grant Agreement link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Long-Term Debt link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Warrants link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Net Loss per Share of Common Stock link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Manufacturing Agreement link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Subsequent Event link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Organization and Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Investments and Fair Value Measurement (Tables) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Stock-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Net Loss per Share of Common Stock (Tables) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Organization and Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Investments and Fair Value Measurement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Summary of Cash, Cash Equivalents and Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Fair Value of Financial Assets and Liabilities by Level within Fair Value Hierarchy (Detail) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Assumptions Used in Black-Scholes Option-Pricing Model to Estimate Fair Value of Pipe Warrants (Detail) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Summary of Changes in Fair Value of Level III Financial Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Research Grant Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Long-Term Debt - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Warrants - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Employee Stock Purchase Plan (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Computation of Basic and Diluted Net Loss Per Share of Common Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Schedule of Outstanding Shares of Common Stock Equivalents Excluded from Computation of Diluted Net Loss Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Manufacturing Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Subsequent Event - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink